The Brain's Own Pain Brake: Descending Inhibition
Part 2C: The Brain's Own Pain Brake: Descending Inhibition · Korean Therapeutic Bodywork Korean Therapeutic Bodywork · A Modern Neuroscience Perspective 34-Part Series Series Home › Section 2: The Neuroscience of Pain › Part 2C Part 2C · Section 2: The Neuroscience of Pain The Brain's Own Pain Brake: Descending Inhibition The brain does not just receive pain signals. It sends signals back down the spinal cord that can actively suppress pain — and manual therapy activates this endogenous analgesic system. The descending inhibitory system — centered on the periaqueductal gray (PAG) and rostral ventromedial medulla (RVM) — is the brain's own built-in analgesic network. When activated, it releases endogenous opioids, serotonin, and norepinephrine back into the spinal dorsal horn, suppressing pain transmission. How the Descending System Works When the PAG–RVM system is activated, it releases...